Selected Publications
Haile M, Kaxiras DA, Zhen J, Jiang B, Lee CL, Small-Saunders JL, Ho CM. Structural basis for host membrane binding and remodeling by invading malaria parasites. Cell. (2026). doi.org/10.1016/j.cell.2026.06.012
Haile M*, Shukla A*, Zhen J, Mather MW, Bhatnagar S, Zhang Z, Vaidya AB**, Ho CM**. Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator. Nature Communications. (2025). doi.org/10.1038/s41467-025-64815-y
Anton L*, Cheng W*, Haile M*, Cobb DW, Zhu X, Han L, Li E, Nair A, Ke H, Zhang G, Doud EH, Ho CM**. Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug. Nature Structural and Molecular Biology. (2025). doi.org/10.1038/s41594-025-01632-3
Anton L, Cobb DW, Ho CM*. Structural parasitology of the malaria parasite Plasmodium falciparum. Trends in Biochemical Sciences. (2021).
Ho CM*, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH*. Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition. Proceedings of the National Academy of Sciences 118 (35), e2100514118 (2021).
Beck JR, Ho CM. Transport mechanisms at the malaria parasite-host interface. PLOS Pathogens 7 (4), (2021).
Ho CM*, Li X*, Lai M, Terwilliger TC, Beck JR, Wohlschegel JA, Goldberg DE, Fitzpatrick AWP, Zhou ZH. Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu. Nature Methods 17, 79-85 (2020). doi:10.1038/s41592-019-0637-y.
Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH. Malaria parasite translocon structure and mechanism of effector export. Nature 561, 70-75 (2018).